For example, the SNP rs12672468 was found to be a vitamin D-only response eQTL associated with expression of ZC3HAV1 encoding a zinc-finger protein previously implicated in colorectal cancer [26] and innate immune responses [27] that highlights potential new mechanisms of 1,25D actions in the colon that could contribute to differences in disease risks. Here, ZNF146 is linked to colorectal cancer.