VDR appeared to be the dominant mediator of genomic effects, and, while several other TFs were found to be enriched among DA peaks, TFs previously reported to co-localize with VDR in a leukemia cell line (i.e., PU.1, CEBPA, GABPA) [41] were not found to be enriched in the colon. The gene discussed is VDR; the disease is leukemia.