LRRK2 and Parkinson disease: In this study, twelve LRRK2 missense variants, p.A419V, p.P755L, p.I786F, p.C925Y, p.M968K, p.R1067Q, p.R1320S, p.I1339M, p.P1446L, p.D1756Y, p.H2206Y, and p.G2385R, were identified in 14.74% of PD cases and 7.24% of control subjects.