Additional results established that Zn-Quer NZs inhibitGC cell proliferation, suppress angiogenesis and EMT, and downregulateNOX4 while promoting apoptosis through the BCL-2/BAX/Caspase3 pathway.Finally, in vivo xenograft experiments showed reduced tumor growthaccompanied by a favorable safety profile, thus emphasizing the translationalpotential of Zn-Quer NZs. The gene discussed is BCL2; the disease is neoplasm.