NOX4 and gastric cancer: NOX4-generated ROS have been shown to promoteEGFR upregulation and anoikis resistance in gastric cancer cells,further supporting its role as a key pro-tumorigenic node. Likewise, ROS-mediated redox signaling is essentialfor orchestrating EMT programs, cytoskeletal remodeling, and metastaticdissemination. Therefore, reducing ROS(particularly NOX4-derived ROS) does not simply protect normal cellsbut directly disrupts the oxidative signaling machinery required fortumor aggressiveness.