Studies have shown that the accumulationof ROS in gastric cancercells is closely related to tumor proliferation, promotion of invasion,distant metastasis, angiogenesis, and regulation of the tumor microenvironment.−, , ,  Excessive accumulation of ROS can lead to DNA damage, promote mutationevents, and alter the expression of tumor-related genes._ROS can alsostimulate various MAPK family pathways and receptor tyrosine kinases(RPTKs), facilitating tumor metastasis. This evidence concerns the gene NTRK1 and neoplasm.