Most studies of racial and ethnic or socioeconomic disparities in colorectal cancer have relied upon data from population-based cancer registries, such as the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program.3,5 Although these data are an important source of cancer information in the US, they overrepresent urban and foreign-born populations and lack detailed information on cancer treatment and tumor-related characteristics (eg, microsatellite instability, BRAF or KRAS variants). The gene discussed is BRAF; the disease is cancer.