IGLL5 and lymphoid neoplasm: Notably, IGLL5, which encodes the immunoglobulin lambda-like polypeptide 5, a protein involved in memory B cell expansion [71] and ​​lymphoid neoplasms reported by COSMIC [72], exhibited blood somatic variants across several individuals; all of these variants were enriched in the N-terminus of the protein (Fig. 5E), consistent with findings from a prior CHIP study based on DNA-seq data [70].