EXT2 and central nervous system cancer: KIF20A is a tumour-associated antigen involved in glioma cell growth and survival [79], EXT2 has been established as a prognostic and predictive biomarker for head-neck squamous cell carcinoma [80], CLDN12 is overexpressed in colorectal carcinomas [81], MBNL2 suppresses tumorigenesis [82], MED18 is part of the Mediator Complex and is a gastric cancer tumour suppressor [83, 84], and DKC1 promotes cell proliferation and metastasis formation in colorectal cancer [85, 86].