We found that the rs3087967 SNP, associated with malignant tumour of the colon, is located in the 3′UTR of the oncogene POU2AF2/C11orf53 [41–43] and creates an ectopic DplUSE consensus, causing a gain of function of the mRNA in vivo in the zebrafish gut and in a human cell line, suggesting its involvement in colon cancer. The gene discussed is POU2AF2; the disease is malignant colon neoplasm.