PTBP1 and nervous system disorder: We also show that depletion of hnRNP C, HuR, and PTBP1, the binding partners of DplUSE, in a human cell line, affects the expression of several genes from the pool of the 31 DplUSE-containing genes that are common to zebrafish, mouse, and humans and that are enriched for association with human diseases such as nervous system diseases, congenital abnormalities, and malignant neoplasms.