NFE2L2 and neoplasm: For example, the copper-quinone-glucose oxidase nanoparticles with self-destructive and multi-enzyme activities (abbreviated as CQG NPs) designed by Luying Qiao can inhibit the Nrf2 and NQO1 signaling pathway to disrupt the antioxidant defense machinery of tumor cells and induce cuproptosis in tumor cells, suggesting that the Nrf2 signaling pathway holds a key position in cuproptosis-related tumor treatment [88].