FOS and periodontitis: Finally, the transcription factors <i>FOS</i>, <i>JUN</i>, <i>RELA</i>, <i>TP53</i>, <i>EGR1</i>, and <i>NFκB1</i> were identified as master regulators (MR-TFs) of inoculation-induced murine periodontitis and were conserved in human regulatory networks.IMPORTANCEPeriodontitis is the most common osteolytic disease in humans, significantly affecting oral health and worsening various systemic inflammatory conditions.