Finally, the transcription factors <i>FOS</i>, <i>JUN</i>, <i>RELA</i>, <i>TP53</i>, <i>EGR1</i>, and <i>NFκB1</i> were identified as master regulators (MR-TFs) of inoculation-induced murine periodontitis and were conserved in human regulatory networks.IMPORTANCEPeriodontitis is the most common osteolytic disease in humans, significantly affecting oral health and worsening various systemic inflammatory conditions. This evidence concerns the gene NFKB1 and periodontitis.