Finally, the transcription factors <i>FOS</i>, <i>JUN</i>, <i>RELA</i>, <i>TP53</i>, <i>EGR1</i>, and <i>NFκB1</i> were identified as master regulators (MR-TFs) of inoculation-induced murine periodontitis and were conserved in human regulatory networks.IMPORTANCEPeriodontitis is the most common osteolytic disease in humans, significantly affecting oral health and worsening various systemic inflammatory conditions. The gene discussed is RELA; the disease is periodontitis.