This mutation is one of the three commonmutation sites in Leber’s hereditary optic neuropathy (LHON) disease (the othertwo common pathogenic mutations are m.11778G>A in the MT-ND4 gene andm.3460G>A in the MT-ND1 gene) [6]. This evidence concerns the gene MT-ND4 and Leber hereditary optic neuropathy.