NOS2 and osteoarthritis: Key inflammatory mediators such as Interleukin‐1 beta (IL‐1β) and Inducible Nitric Oxide Synthase (iNOS) promote the expression of matrix metalloproteinases (MMPs) and aggrecanases, which collectively accelerate the degradation of extracellular matrix and the progression of osteoarthritis (OA) [3, 4].