In addition, genes related to immune activation, such as Nfkb, Myd88, were increased in CIPO mice, while Nos2 and Il17A were downregulated compared with HC mice, with multiple genes involved in barrier function being altered (Cldn2, Ocln, Cdh1), altogether suggesting profound changes within the neuroimmune system of the murine host. The gene discussed is NOS2; the disease is chronic intestinal pseudoobstruction.