The following 16 parameters showed a statistical difference between AIH patients with and without cirrhosis: age, ALB, GLO, ALT, AST, ALP, WBC, Hb, PLT, IgG, C3, C4, ANA titer, and comorbidities such as depression, extrahepatic AIDs, and enlarged ALN (Table S3). This evidence concerns the gene C4A and major depressive disorder.