NETosis can improve the effectiveness of dendritic cell (DC) vaccines against acute myeloid leukaemia (AML). NETosis promotes the exposure of mutant nucleophosmin (NPMc+), which relocates from the nucleolus to the cytoplasm when mutated. These antigens can be utilised as a source for DC‐mediated antigen presentation. The gene discussed is NPM1; the disease is acute myeloid leukemia.