Two unrelated patients have been reported with de novo TUBB2A variants at the same amino acid position, p.(V49M) and p.(V49G), showing overlapping features with our case including microcephaly (1/2), dysmorphic features (1/2), intellectual disability (2/2), dysgyria (1/2), thinning of the corpus callosum (1/2), and a small cerebellum (1/2). The gene discussed is TUBB2A; the disease is microcephaly.