MC1R and Parkinson disease: When stratifying by sex, although the rate of change in MDS-UPDRS III was numerically different between males with MC1R PD (2.49; β diff=0.44 (−0.02 to 0.90) p=0.063) and females with MC1R PD (2.24; β diff=0.44 (−0.43 to 1.31) p=0.324), the effect of MC1R relative to sporadic PD appeared similar across sexes (Table 3).