Here, we analyzed longitudinal data from 802 PD participants in the PPMI cohort, including 185 with sporadic PD, 220 with MC1R PD, 84 with LRRK2 PD, 43 with GBA PD, 187 with MC1R + LRRK2 PD, and 83 with MC1R + GBA PD. This evidence concerns the gene LRRK2 and Parkinson disease.