Finally, compared to patients with persistently low NT-proBNP levels, no significant difference in the primary outcome was observed in those who exhibited a postprocedural reduction in NT-proBNP (aHR 1.18; 95% CI 0.47–3.00), while those with postprocedural NT-proBNP elevation (aHR 2.25; 95% CI 1.00–5.05) and those with persistently high levels (aHR 2.32; 95% CI 1.25–4.31) had significantly greater risk (Figure 5), based on models adjusted for sex, BMI, anaemia, LVEF, COPD, dyslipidaemia, atrial fibrillation, and chronic kidney disease (Table 5). This evidence concerns the gene NPPB and chronic obstructive pulmonary disease.