Over a 2-year follow-up, patients with elevated NT-proBNP levels at baseline experienced a significantly higher incidence of the composite endpoint of all-cause mortality or HF rehospitalization compared to those with low baseline levels (26.1% vs. 13.7%; HR 2.23, 95% CI 1.51–3.28; Figure 4A). Here, NPPB is linked to hydrops fetalis.