The age, BMI, weight, polycystic ovarian syndrome, smoking history, severe endometriosis, prior ovarian response, prior pelvic surgery, AFC, ovarian volume, ovarian stromal blood flow, serum AMH, serum FSH, serum luteinizing hormone, serum estradiol, serum inhibin B, serum testosterone, and various dynamic tests of ovarian reserve are all important factors to consider when determining the starting dose of r-FSH. The gene discussed is BRD2; the disease is polycystic ovary syndrome.