Laboratory investigations (Table 1) revealed a markedly reduced morning serum cortisol level (0.3 μg/dL) accompanied by a significantly elevated ACTH concentration (3593 pg/mL), confirming the diagnosis of ACTH-resistant adrenal insufficiency. No ACTH stimulation test was performed, as the combination of clinical features and biochemical findings was considered sufficient to establish the diagnosis. Here, POMC is linked to Adrenal insufficiency.