Current study demonstrated that CYP1B1 played an important role in fatty acid metabolism and that CYP1B1-SCD1 inhibition significantly attenuated high-fat diet-induced NAFLD, improved glucose tolerance and prevented hepatic steatosis (Larsen et al., 2015, Liu et al., 2015). The gene discussed is CYP1B1; the disease is metabolic dysfunction-associated steatotic liver disease.