Efficacy of progestin therapies may be limited by progestin resistance or intolerable side effects, and long-term use of GnRH agonists and antagonists is limited by potential hypoestrogenic effects, including hot flushes, hyperlipidemia, and loss of bone mineral density (BMD).8, 9, 10 Nonsurgical therapies that safely provide long-term symptom relief to women with endometriosis are needed. The gene discussed is GNRH1; the disease is endometriosis.