EIF4E and neoplasm: Consistently, antisense oligonucleotide-mediated downregulation of eIF4E suppresses tumour growth in xenograft models.44 Moreover, studies in eIF4E haplo-insufficient mice revealed that a 50% reduction in eIF4E is compatible with normal development and global protein synthesis, yet is sufficient to block cellular transformation.45 Thus, there is an interest in targeting eIF4E for degradation by induced-proximity approaches.