To demonstrate proof-of-concept, we targeted eIF4E, a key component of the eIF4F translation initiation complex, which also includes eIF4A and eIF4G, and plays a vital role in binding the 5′ cap of mRNA to facilitate translation.39 Overexpression of eIF4E has been linked to hallmarks of cancer such as uncontrolled cell growth and proliferation.40–43 Cancer-dependency analyses further show that many different cancer cell types rely heavily on eIF4E for survival (https://depmap.org/portal). This evidence concerns the gene EIF4G1 and cancer.