This was incidentally discovered as a PSMA (prostate-specific membrane antigen)-positive lesion on PSMA-positron emission tomography (PET)-computed tomography (CT) in a patient with synchronous prostate cancer (PCa).The expanding utilization of PSMA-PET-CT has revealed tracer uptake in several nonprostatic conditions. The gene discussed is FOLH1; the disease is Familial prostate cancer.