Hence, PET-CT reporters should correlate molecular factors (intensity and extension different from other lesions or from those expected to occur in PCa), morphological factors (CT/MRI findings characteristic of a specific neoplasm or of a PCa lesion), biological factors (known PCa staging, predicted spread, PSA values), and clinical factors (underlying condition that can explain PSMA positivity).1 Here, FOLH1 is linked to posterior cortical atrophy.