APC and Familial adenomatous polyposis: Among patients with FAP, desmoid tumors develop in approximately 8%–20% of individuals.2,3) In FAP-associated cases, tumor locations include intra-abdominal (53%), abdominal wall (24%), and extremities (9%), with the remainder being unknown or multiple sites.2) Identified risk factors for desmoid tumor development include prior abdominal surgery, an APC gene mutation at codon 1444, and a family history of desmoid tumors.2)