AlzhCPI, an ML-basedweb server employingrecursive partitioning and Naïve Bayes algorithms, exemplifiespredictive modeling for compound–target interactions in AD.Similarly, various studies have adopted SVM SVMs, RF, and DNNs toidentify inhibitors targeting pathological enzymes and receptors suchas acetylcholinesterase and S100A9. Inthe context of PD, Quan et al. proposed a network-based bidirectionaldrug repositioning approach based on PPI networks, identifying ten potential therapeutic candidates. This evidence concerns the gene ACHE and Alzheimer disease.