APP and Alzheimer disease: For instance, carmustinehas been shown to significantly reduce amyloid-β productionin APP-overexpressing cell models, whilebexarotene effectively reversed neurodegeneration and lowered amyloid-βlevels in transgenic AD mouse models. Similarly, tamibarotene, a retinoid receptor agonist, exhibitedmultitarget activities, including anti-inflammatory effects and behavioralimprovements.