EGFR and neoplasm: Its function in promoting tumor invasion and metastasis through downstream activation of the Phosphatidylinositol 3-kinase (PI3K)/also called phosphoinositide 3-kinase (PI3K), and Mitogen-Activated Protein Kinase (MAPK) pathways has been highlighted by the observation of dysregulation of the epidermal growth factor receptor (EGFR), which is frequently linked to mutations or amplifications [44].