Immunohistochemistry (IHC) analysis of a human GC tissue microarray (TMA) containing 114 paired tumor tissues (T) and adjacent non-tumor tissues (N) (Fig. 1A) revealed that 71.1% of tumor samples exhibited high CBX4 expression (39 cases ‘+++’ and 42 cases ‘++’), while 28.9% had low expression (21 cases ‘+’ and 12 cases ‘−’) (Fig. 1B,C). The gene discussed is CBX4; the disease is neoplasm.