In accordance with the 2025 National Comprehensive Cancer Network (NCCN) Guidelines, B-ALL is classified into the following risk categories: Standard Risk: including such as high hyperdiploidy and ETV6::RUNX1 subtypes; High Risk: TCF3::PBX1 and BCR::ABL1 (Ph+) subtypes; Very High Risk: BCR::ABL1-like (Ph-like) and KMT2A-rearranged subtypes [4]. This evidence concerns the gene ABL1 and acute lymphoblastic leukemia.