Previous studies have shown that IL-17F suppresses VM in oral tongue squamous cell carcinoma [35]; HIF-1α/EphA2/Laminin-5γ2 axis downregulation inhibits hypoxia-induced VM in oral cancer [36]; SOX7 inhibits VM by downregulating VE-cadherin in OSCC [37]. Here, CDH5 is linked to lip and oral cavity carcinoma.