VEGFA and cancer: Specifically, damage-associated molecular patterns (DAMPs) released during ferroptosis induce the secretion of inflammatory cytokines such as interleukin-8 (IL-8) as well as recruit and activate various immune cells (e,g., tumor-associated macrophages, myeloid-derived suppressor cells, regulatory T cells), directly promoting cancer cell proliferation, while upregulating pro-angiogenic factors like vascular endothelial growth factor (VEGF) to accelerate tumor vascularization [82].