PTGS2 and colorectal carcinoma: In addition, Tanshinone IIA has been found to promote ferroptosis in cutaneous melanoma via STAT1-mediated upregulation of prostaglandin-endoperoxide synthase 2 (PTGS2) expression [100] and in colorectal cancer (CRC) through the suppression of SLC7A11 expression via the PI3K/AKT/mTOR pathway [101].