In melanoma, several ETS TFs, including FLI1, SPI1, ELF4, ETV7, SPIB, and SPIC, are expressed at higher levels in Cluster A patients, whereas ETV5, ETV4, ELK1, ERF, and ETV2 showed increased expression in Cluster B patients (Fig. 1E). This evidence concerns the gene SPI1 and melanoma.