CD274 and neoplasm: This evasion is facilitated through multiple mechanisms, including the elevated expression of immune checkpoints such as programmed death-ligand 1 (PD-L1), defective antigen presentation process, and the infiltration of immune-suppressing cells, such as myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs), into the tumor microenvironment (TME) [1–3].