In Cluster B melanomas, which exhibited worse prognosis, the expression levels of ETV2, ERF, ELK1, ETV4, and ETV5 were higher compared to those in Cluster A. Therefore, our study suggests that the expression patterns of the ETS family members reflect the immune landscape and are involved in regulating anti-tumor immune activity within the melanoma TME. This evidence concerns the gene ETV5 and melanoma.