Analysis of gene signatures of the hallmark pathways highlighted that immune-related signatures, such as IL6/JAK/STAT3 signaling, inflammatory response, and interferon-gamma response, were significantly enriched in Cluster A patients, while MYC targets and glycolysis, which contribute to tumor progression, were the top enriched signatures in Cluster B patients (Fig. 2A). This evidence concerns the gene STAT3 and neoplasm.