Glycerolipid metabolism-related genes 1-acylglycerol-3-phosphate O-acyltransferase 3 (AGPAT3) and aldehyde dehydrogenase 7 family member A1 (ALDH7A1) were identified as key prognostic genes in osteosarcoma, with high AGPAT3 expression correlating with improved survival. This evidence concerns the gene ALDH7A1 and osteosarcoma.