The role of ZMIZ2 in regulating MAPK signaling may depend on various cellular factors, such as the tumor microenvironment [54] and stage of tumor progression, or it may be counterbalanced by the activation of other oncogenic pathways, such as the PI3K/AKT/mTOR pathway, which is known to cooperate with Ras/MAPK signaling in cancer [55]. The gene discussed is AKT1; the disease is cancer.