NR4A triple knockout CAR tumor-infiltrating lymphocytes displayed phenotypes and gene expression profiles characteristic of CD8+ effector T cells, and chromatin regions uniquely accessible in NR4A triple knockout CAR tumor-infiltrating lymphocytes were enriched for binding motifs for NF-κB and AP-1; both are transcription factors involved in activation of T cells.95 This evidence concerns the gene JUN and neoplasm.