GCG and Hypoglycemia: The increased glucagon response with SSTR2a was also observed during hypoglycemia (study B) at a 10-fold lower dose than was used in study A, and no decline in baseline glucagon occurred over time in study B. A sustained effect with repeated SSTR2a dosing has also been reported in a study to assess tachyphylaxis in nondiabetic Sprague-Dawley rats (21).