Furthermore, antecedent hypoglycemia affected glycemic parameters, but not the glucagon response in SSTR2a-treated rats, as blood glucose nadirs were lower (P < .01) and blood glucose AUC less than 3.9 mmol/L higher (P < .0001) in challenges 3 and 4 than in the first 2 challenges (Table 1). The gene discussed is GCG; the disease is Hypoglycemia.