KEGG analysis identified the top 20 significantly enriched pathways in SS, including estrogen signaling, immune response (e.g., Staphylococcus aureus infection, Fc gamma‐R‐mediated phagocytosis), hormone regulation (GnRH, relaxin, and parathyroid hormone), synaptic pathways (serotonergic, dopaminergic, cholinergic), VEGF signaling, mTOR signaling, and cancer‐related pathways (choline metabolism, bladder cancer) (Figure 3). The gene discussed is GNRH1; the disease is cancer.