Cardiac tissues were analyzed for AGE deposition, AGE receptors expression, oxidative stress markers, cytokine profiles, and histological changes, including fibrosis and inflammation.<h4>Results</h4>Aerobic exercise in T2D mice reduced the cardiac deposition of fluorescent AGEs and CML, decreased RAGE protein and gene expression, downregulated CD36 and galectin-3 receptors, while not affecting GLO-1 detoxification system. This evidence concerns the gene CD36 and type 2 diabetes mellitus.