<h4>Background</h4>N-acetyltransferase 10 (NAT10) mediated N4-acetylcytidine (ac4C) modification has been implicated in tumor progression; however, the precise role and underlying mechanism of NAT10 in breast cancer progression remain largely undefined.<h4>Methods</h4>The expression and prognostic significance of NAT10 in breast cancer were evaluated using clinical tissue samples and public databases. This evidence concerns the gene NAT10 and breast cancer.