PIK3CA and hepatocellular carcinoma: RG3 modulates several critical signaling pathways, including PI3K/AKT, NHE1/EGF-EGFR-ERK1/2-HIF-1α, IFN-γ/IL-2, ROS/LC3 II, ARHGAP9, and PCNA/cyclin D1 in HCC [14–17].