T2DM mice also exhibited M1 macrophage persistence (elevated CD68 in wound and elevated IL-6, TNF-α, iNOS in serum) and M2 macrophage deficiency (reduced CD206 in wound and decreased IL-10, TGF-β, Arg-1 in serum), with impaired myofibroblast activity (α-SMA) and angiogenesis (CD31). This evidence concerns the gene TGFB1 and type 2 diabetes mellitus.