The primary objectives of the present study were to (1) determine the prevalence of muscle cramps, neuropathic pain, and symptoms of autonomic dysfunction in ataxic and pre-ataxic SCA3 mutation carriers and (2) evaluate the relationship between the severity of PNS and ANS involvement with overall ataxia severity, activities of daily living, and quality of life. This evidence concerns the gene ATXN3 and Ataxia.