We then correlated radial distance with individual genes and metabolite peaks to find molecules localised to specific regions (Fig. 5e), including genes high in tumour core corresponding to known epithelial (luminal) tumour markers (e.g., KRT8, KRT19, FOXA1), to RTK-linked signalling and motility (e.g., ERBB2, DDR1, ENAH), and to metabolic reprogramming and stress responses (e.g., FASN, S100A1). Here, S100A1 is linked to neoplasm.