e.g., CCL14, ACKR1, TGFBR2, and markers representing the more structured vasculature outside the tumour core, e.g., PECAM1, VWF, CDH5, CLDN5, CD93. The metabolic profile of the distal region was predominantly characterised by glucose (m/z 215.03267), the top positively correlated peak, in agreement with reports of pronounced glucose depletion observed in the tumour core relative to the surrounding stroma62. The gene discussed is CLDN5; the disease is neoplasm.