EIF3A and hepatocellular carcinoma: The types of RNA methylation also differ and include m6A, m1A, m5C, m1G, m7G, m5U, etc. Research has shown that m6A methylation plays an important role in tumors; for example, METTL16, an enzyme responsible for RNA m6A modification, interacts with EIF3A/B in hepatocellular carcinoma (HCC) cells, mainly through the R1 and R2 regions of METTL16.