Leveraging transcriptomic data from 48 orthotopic liver transplant (OLT) patients in the Sosa et al. dataset—one, if not the only, of the few datasets including paired pre- and post-ischemia samples—we found significant upregulation of iRhom2 transcripts in IRI+ patients post-reperfusion [11, 16]. This evidence concerns the gene RHBDF2 and ischemia.