In contrast, a recent study has demonstrated that A3C depletion slows replication fork progression in HPAF-II pancreatic cancer cell line but not in RPE1-hTERT p53−/− cells, further emphasizing the necessity to consider p53 status and cellular context when interpreting the function of A3C in replication fork regulation [7]. The gene discussed is APOBEC3C; the disease is familial pancreatic carcinoma.