Herein, we report the synthesis, characterization,preclinical imaging, and ex vivo biodistributionanalysis of a novel immunoSCIFI probe, [89Zr]­Zr-DFO-MT1-MMP-BOD665,based on a murine monoclonal immunoglobulin G (IgG) with high bindingspecificity for the sarcoma biomarker MT1-MMP. Here, MMP14 is linked to sarcoma.