Next, we tested the first gene set that was associated with COVID-19 severity in 2020,53 focusing on genes involved in regulating type I and III interferon-mediated immunity (nominally, TLR3, IRF7, IRF9, TICAM1, UNC93B1, TRAF3, TBK1, IRF3, IKBKG, IFNAR1, IFNAR2, STAT1, and STAT2). Here, IRF3 is linked to COVID-19.