LGR5 and COVID-19: To confirm the genetic association of the LPO locus (chr17:58247557-58267935, hg38 coordinates) with COVID-19 in an independent cohort, we retrieved data from the RGC browser (https://rgc-covid19.regeneron.com/home, accessed on 2 April 2025), which includes genome-wide association studies (GWAS) of COVID-19 outcomes across 756,646 individuals (of which >50,000 with COVID-19), derived from four projects: UKB (N = 459,027), AncestryDNA COVID-19 Research Study (N = 163,650), GHS (N = 118,017), and Penn Medicine BioBank (N = 15,952).