The biallelic ZNF808 genotype of individuals with adolescent-onset diabetes also distinguishes the disease caused by ZNF808 variants from other PA genes that cause both PNDM and adolescent/adult-onset diabetes, such as RFX6 and PDX1, where the later-onset diabetes occurs through dominantly acting variants, while neonatal-onset diabetes is caused by recessively acting variants.7 This evidence concerns the gene RFX6 and type 2 diabetes mellitus.