Notably, the increased H2Aub levels, triggered by EnP1 or Encephalitozoon hellem (Eh) infection, facilitated the upregulation of SLC7A11 by enhancing the binding affinity of H2Aub to the SLC7A11 promoter, representing a key mechanism through which microsporidia counteract host cell ferroptosis during infection. This evidence concerns the gene SLC7A11 and infection.