It has been fully established that CaMKII plays an important role in myocardial hypertrophy, pressure overload induced cardiac hypertrophy and fibrosis, ischemia/reperfusion (I/R) injury, heart failure (HF), post myocardial infarction (MI) remodeling, and ventricular arrhythmias [13–18]. The gene discussed is CAMK2G; the disease is heart failure.