TP53 and lung adenocarcinoma: For a proof-of-conceptstudy, we utilized an autochthonous, conditional KrasLSL.G12D/wt;Trp53fl/fl (KP) mouse model., In this mouse model for highly aggressive lung adenocarcinoma, weinduced tumor formation by intratracheal Adeno-CMV-Cre instillation,leading to KrasG12D activation and Trp53 deletion (Figure a), and monitoredtumor onset via μCT imaging.