For PDEδ as a lipoprotein chaperone involvedin membrane localization and hence proper signaling of GTPases, includingRas,−,  targeting PDEδ may also offer an alternativestrategy to treat K-Ras-driven cancers, evidenced from the clear effectivenessof Deltafluorine demonstrated in the in vivo KrasLSL.G12D/wt;Trp53fl/fl (KP) mouse model of lung adenocarcinoma. Here, PDE6D is linked to lung adenocarcinoma.